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KMID : 0603820170230030281
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Journal of Experimental & Biomedical Science
2017 Volume.23 No. 3 p.281 ~ p.285
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Ixeris dentata (Thunb) Nakai Attenuates Cognitive Impairment in Scopolamine-induced Amnesic Mice
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Lee Sung-Gyu
Kim Ki-Whan
Kang Hyun
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Abstract
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The purpose of the current study is to investigate the cognition-enhancing effects of Ixeris dentata (Thunb) Nakai in
scopolamine-induced amnesic mice. Scopolamine (2 mg/kg, i.p.) was used to induce amnesia in mice. The cognitiveenhancing activity of the IDE (10, 20 and 40 μg/mL) was studied by passive avoidance response, elevated plus maze and Y-maze behavioral paradigm in normal and scopolamine-induced amnesic mice. Scopolamine-induced cognitive deficits were significantly reversed by IDE (P < 0.001 at 20 mg/kg) in a dose-dependent fashion in all the behavioral paradigms tested. IDE possesses cognitive-enhancing properties in amnesic mice due to its potent antioxidant action.
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KEYWORD
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Ixeris dentata , Cognition , Scopolamine , Antioxidant , Amnesia
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